Identification of Key Differentially Expressed Transcription Factors in Glioblastoma
نویسندگان
چکیده
منابع مشابه
In silico Analysis of Transcription Factors Associated to Differentially Expressed Genes in Irradiated Glioblastoma Cell Lines
Glioblastoma multiforme (GBM) is one of the most frequent tumors in the central nervous system and the most malignant tumor among gliomas. In the past two decades, cytogenetic and molecular genetic studies have identified a number of recurrent chromosomal abnor‐ malities and genetic alterations in malignant gliomas, particularly in GBM [1]. It was already described that GBM harbors combinations...
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The present study aimed to identify differentially expressed genes (DEGs) regulated by transcription factors (TFs) in glioblastoma, by conducting a bioinformatics analysis. The results of the present study may provide potential therapeutic targets that are involved in the development of glioblastoma. The GSE4290 raw data set was downloaded from the Gene Expression Omnibus database, and consiste...
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The loss of large segments or an entire copy of chromosome 10 is the most common genetic alteration in human glioblastomas. To address the biological and molecular consequences of this chromosomal alteration, we transferred a human chromosome 10 into a glioma cell clone devoid of an intact copy. The hybrid cells exhibited an altered cellular morphology, a decreased saturation density, and a sup...
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ژورنال
عنوان ژورنال: Journal of Oncology
سال: 2020
ISSN: 1687-8450,1687-8469
DOI: 10.1155/2020/9235101